By Gebhard Flatz (auth.), Harry Harris, Kurt Hirschhorn (eds.)
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1980). Hydrogen derived from metabolism of lac- 24 Gebhard Flatz tose by colonic bacteria in subjects with low LDC is excreted through the lungs and serves as the diagnostic parameter. Gas chromatographic determination of breath hydrogen concentration after a lactose load is a convenient, noninvasive method for assessing lactose digestion capacity. , 1976) and can be stored for several hours in plastic syringes (Rosado and Solomons, 1983). , 1981). , 1985). , 1982a). In clinical investigations, breath samples are collected at intervals of 15-30 min after lactose administration for 3-4 hr.
In these areas, the allele LAC*P may be completely absent in populations unaffected by admixture with Europeans. In the population groups that migrated to the Americas in historical times, lactase phenotype distribution reflects that in the areas of origin: white Americans have high frequencies of high LDC and black Americans high frequencies of low LDC. In mixed populations, lactase phenotype distribution is intermediate to the parental groups. , 1977). The American distribution data are listed geographically in Table IV.
01). From Paul and Flatz (1983). of lactase activity in suckling rats. Administration of glucocorticoids and thyroxine accelerates the reduction in lactase activity. The effect of thyroxine was compared to the metamorphosis of the axolotl, which is known to be triggered by thyroid hormone . In most of the animal studies, the observation period after hormone administration was short and it was assumed that the effect on lactase activity was irreversible. If lactase activity after thyroxine administration to suckling rats is followed for a long period, it emerges that the decrease in activity is transitory: lactase activity returns to the normal age-specific level before the low adult activity values are reached (Paul and Flatz, 1983) (see Fig.