Applying pharmacogenomics in therapeutics by Xiaodong Feng, Hong-Guang Xie

By Xiaodong Feng, Hong-Guang Xie

Recent advances in high-throughput gene sequencing and different omics biotechnologies have served as a springboard for the sphere of pharmacogenomics. Pharmacogenomics is now as a rule approved because the significant determinant of variable drug safeguard, efficacy, and cost-effectiveness. for that reason, common use of pharmacogenomics for sufferer care has turn into a severe requirement. there's an unheard of urgency for aspiring and working towards clinicians to develop into educated on how one can interpret info from pharmacogenomic checking out in practise for the way forward for healthcare―i.e., customized medicine.

Applying Pharmacogenomics in Therapeutics offers well timed assurance of the foundations, perform, and strength of pharmacogenomics and custom-made medication. made out of chapters contributed by way of well-established pharmacologists and scientists from US and chinese language academia and undefined, this authoritative text:

  • Demonstrates easy methods to follow the rules of pharmacogenomics and its biotechnologies in sufferer care
  • Depicts using genetic biomarkers in drug discovery and improvement, laboratory medication, and medical services
  • Describes the perform of pharmacogenomics within the remedy of cancers, cardiovascular ailments, neurologic and psychiatric problems, and pulmonary diseases
  • Discusses the merging of pharmacogenomics and replacement medication, in addition to the combination of pharmacogenomics into pharmacoeconomics

Each bankruptcy starts off with the foremost recommendations, through in-depth explorations of case stories or severe reviews of genetic variants/biomarkers, and concludes with questions for self-examination.

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Black Golde, and N. Berlinger. Ethical considerations in CYP2D6 genotype testing for codeine-prescribed breastfeeding mothers. Clin Pharmacol Ther, 2010; 88(6): 760–2. Codeine. Breast feeding. Clinical pharmacology. 2011. cpnum=146&sec=​ monpreg (accessed August 30, 2011). E. Did the drug cause death? Codeine and breastfeeding. Lancet, 2008; 372(9639): 606–8. 126. , et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Engl J Med, 2004; 351(27): 2827–31. 127. Madadi, P. and G.

40 NGS Technology.................................................................................................. 42 Concluding Remarks................................................................................................. 45 Study Questions........................................................................................................ 46 KEY CONCEPTS • Pharmacogenetics reveals the determinants of genetic variations in drug responses across individuals. • The rapid development of biotechnologies to precisely identify DNA variations is one of the major driving forces in this field.

He is considering surgical options for his chronic back pain because he does not want to become “dependent” on his medications, and he has had numerous side effects from his medications. 107–109 It is often combined with other analgesics, such as acetaminophen, for mild-to-moderate pain disorders and postsurgical analgesia. 5–1% in Hispanics; 1–10% in whites; 3% in African Americans; and 16–28% in North Africans, Ethiopians, and Arabs. 109,119,120 For example, UMs have a higher incidence of sedation compared to EMs (91% vs.

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