Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, by Duncan Dartrey Adams

By Duncan Dartrey Adams

This ebook describes how the Jerne-Burnet Forbidden Clone thought and the Adams-Knight H Gene concept, solved the pathogenesis and genetics of the autoimmune illnesses exhibiting how particular immunotherapy and prophylaxis will be constructed. in addition, Ebringer's discovery of 2 microbial triggers of autoimmune illnesses is defined and the realization drawn that each one autoimmune ailments have microbial triggers, so should be preventable via the discovering of the triggers and vaccination opposed to them.

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Additional resources for Autoimmune Disease: Pathogenesis, Genetics, Immunotherapy, Prophylaxis and Principles for Organ Transplantation

Sample text

28. Burnet FM. Autoimmune disease. BMJ. 1959; 2: 645–50 and 720–5. 29. Knight J, Laing P, Knight A, Adams DD. Ling N R. Thyroid-stimulating autoantibodies usually contain only k light chains: evidence for the forbidden clone theory. J Clin Endocrinol Metab. 1986;62:342–7. 30. Pinchera A, Ingbar SH, McKenzie JM, Fenzi GF, editors. Thyroid autoimmunity. New York: Plenum Press; 1987. 31. Adams DD, Knight A, Knight JG, Laing P. Graves’ disease; a paradigm for autoimmunity. In: Pinchera A, Ingbar SH, McKenzie JM, Fenzi GF, editors.

2003;52:1–22. 10.

This needs further exploration, as does the whole field of psychotic aetiology, until the presumptive forbidden clones have been demonstrated with the clarity obtained for Graves’ disease and myasthenia gravis. Post-measles encephalomyelitis. This provided the first example of prophylaxis of an autoimmune disease by vaccination against its microbial trigger. Enders made a vaccine against measles, which rigorous studies by the National Communicable Disease Centre in Atlanta [7] showed gave 700-fold decreased risk of encephalomyelitis compared to the natural infection, as described below.

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