Chromosome 12 Aberrations in Human Solid Tumors: by G. Stenman, J. Bullerdiek, S. Bartnitzke, P. Sahlin, E.

By G. Stenman, J. Bullerdiek, S. Bartnitzke, P. Sahlin, E. Röijer, J. Mark (auth.), Prof. Dr. J. Bullerdiek, Dr. S. Bartnitzke (eds.)

Researchers all for the cytogenetics and molecular genetics of human tumors will welcome this accomplished review of the kind of aberrations that chromosome 12 provides in human reliable tumors. The authors learn the consequences for a cytogenetic subtyping of the tumors concerned and methods for opting for the molecular adjustments which underlie the karyotypic changes.
The aberrations of chromosome 12 which the ebook bargains with are very widespread chromosomal adjustments in human tumors occuring in common benign mesenchymal tumors, akin to uterine leiomyomas and lipomas, and in tumors of epithelial beginning, similar to pleomorphic adenomas of the salivary glands.

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Additional info for Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics

Example text

1986b), and uterine leiomyomas (Heim et a1. 1988; Turc-Carel et a1. 1988; Vanni and Lecca 1988). , cervical polyps (Vanni et a1. 1993) or epithelial hyperplasia of the breast (Rohen et a1. 1993). For the group of pleomorphic adenomas, lipomas, myxoid liposarcomas, and uterine leiomyomas, Schoenmakers et a1. (1993) were able to show that the specific breakpoints in aB tumors mentioned above fell within the 7 cM region between loci D12S19 and D12S8. Other chapters of this book have dealt with details of the cytogenetic findings in these tumors.

Cancer Genet Cytogenet 32:13-17 Karakousis CP, Dal Cin P, Turc-Carel C, Limon J, Sandberg AA (1987) Chromosomal changes in soft-tissue sarcomas: a new diagnostic parameter. Arch Surg 122:1257-1260 Limon J, Dal Cin P, Sandberg AA (1986) Application of long term collagenase disaggregation for the cytogenetic analysis of human solid tumors. Cancer Genet Cytogenet 23:305-313 Mandahl N, Willen H, Rydholm A, Heim S, Mitelman F (1993) Rearrangement of band q13 on both chromosomes 12 in a periosteal chondroma.

1993) were able to show that the specific breakpoints in aB tumors mentioned above fell within the 7 cM region between loci D12S19 and D12S8. Other chapters of this book have dealt with details of the cytogenetic findings in these tumors. Usually, the aberrations of chromosomal region 12q13-15 are the only karyotypic abnormality, thus indicating that a causal relationship between the cytogenetic changes and tumorigenesis exists. However, up to now the molecular analysis of the mechanisms underlying the chromosomal alterations has remained open and can be expected to fully elucidate as to how these changes contribute to tumorigenesis.

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