Developmental Neurobiology by Marcus Jacobson (auth.)

By Marcus Jacobson (auth.)

In our makes an attempt to interrogate Nature concerning the improvement of the frightened process, we ask such questions as "How do the nerve cells originate and the way do the proper forms of cells differentiate at their right positions; how do the neurons hyperlink jointly to shape circuits whose services are correctly coordinated; and the way are the capabilities of nerve cells relating to habit, to notion, and to wide awake­ ness?" these difficulties are intellectually demanding, not just simply because fixing them may supply us functional benefits but additionally simply because whereas they continue to be unsolved they stimulate the mind's eye and problem the intelligence. it really is accurately simply because they're tricky and debatable and feature defied entire resolution that such difficulties proceed to draw refined minds. the certainty that we've of neural ontogeny turns out to me to be further from entire wisdom than from overall lack of expertise. still, it provides us a touch increased place from which to survey the vicissitudes of the earlier, to appraise our current knowing, and to think about ways that our knowl­ facet may possibly strengthen sooner or later. The background of this topic gives a very piquant representation of Arthur Lovejoy's remark that the "adequate list of even the confusions of our forebears can assist, not just to elucidate these confu­ sions, yet to engender a salutary doubt even if we're fully immune from various yet both nice confusions.

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Extra resources for Developmental Neurobiology

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In A the arrow points to the position of the microelectrode tip in the neural tube, and in B the arrow points to the position of the tip of the microelelectrode in the notochord. Both microelectrodes were inside cells, as is shown by the e1ectrical records C, D, and E. 98 sec) shown in C produced e1ectrotonic potential change (E) in the notochord cell, but no potential change just outside the notochord cell, as is shown in record D. Voltage calibration for D and E, 20 m V. From J. D. Sheridan,J.

37 THE GERMINAL CELLAND HISTOGENESIS OF THENERVOUS SYSTEM 38 CHAPTER2 In neuro epithelial germinal eells, as weIl as glioblasts, the duration of mitosis is very short when eompared with the duration ofthe eell eyde. This is refteeted in the paueity of metaphase figures seen at all stages of development of the nervous system. U sually the total fraetion of mitotie figures seen in histologieal preparations of the developing neural tube does not exeeed 2-5 percent. One method of determining the duration of the eell eyde is to count the proportions of labeled and unlabeled mitotie figures in autoradiographs made after administration of [3Hlthymidine.

Jacobson, 1959, 1964; Corner, 1963, 1964). Thus fragments of neural plate, composed entirely of neuroepithelial germinal cells, when cultured in vitro or when transplanted to other parts of amphibian embryos, develop into nervous tissue containing types of nerve cells that would normally have developed from the part of the neural plate from which each explant was derived. One of the questions that has not yet been answered is whether and how the germinal cells at any particular position are programmed to produce specific types of nerve cells.

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