Genetics: Analysis of Genes and Genomes by Daniel L. Hartl

By Daniel L. Hartl

Creation to molecular genetics and genomics -- DNA constitution and DNA manipulation -- Transmission genetics : the primary of segregation -- Genes and chromosomes -- Genetic linkage and chromosome mapping -- Molecular biology of DNA replication and recombination -- Molecular biology of DNA replication and recombination -- Molecular mechanisms of mutation and DNA fix -- Molecular association of chromosomes -- Human karyotypes and chromosome habit -- Genetics of micro organism and their viruses -- Molecular biology of gene expression -- Molecular mechanisms of gene legislation -- Genetic engineering and genomics -- Genetic keep an eye on of improvement -- Molecular genetics of the mobile cycle and melanoma -- Extranuclear inheritance -- inhabitants genetics and evolution -- The genetic foundation of complicated inheritance

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Genetics: Analysis of Genes and Genomes

Advent to molecular genetics and genomics -- DNA constitution and DNA manipulation -- Transmission genetics : the primary of segregation -- Genes and chromosomes -- Genetic linkage and chromosome mapping -- Molecular biology of DNA replication and recombination -- Molecular biology of DNA replication and recombination -- Molecular mechanisms of mutation and DNA fix -- Molecular association of chromosomes -- Human karyotypes and chromosome habit -- Genetics of micro organism and their viruses -- Molecular biology of gene expression -- Molecular mechanisms of gene rules -- Genetic engineering and genomics -- Genetic regulate of improvement -- Molecular genetics of the mobile cycle and melanoma -- Extranuclear inheritance -- inhabitants genetics and evolution -- The genetic foundation of advanced inheritance

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Today, genetically engineered corn, soybeans, and other crops constitute a significant proportion of all the food produced worldwide. The pharmaceutical industry is another area in which genetics plays an important role. Numerous drugs and food additives are synthesized by fungi and bacteria that have been genetically manipulated to make them efficient producers of these substances. 2 Genes influence susceptibility to many diseases and disorders. (a) An X-ray of the hand of a person suffering from diastrophic dysplasia (bottom), a hereditary growth disorder that results in curved bones, short limbs, and hand deformities, compared with an X-ray of a normal hand (top).

All of this information provides us with a better understanding of numerous biological processes and evolutionary relationships. The flood of new genetic information requires the continuous development of sophisticated computer programs to store, retrieve, compare, and analyze genetic data and has given rise to the field of bioinformatics, a merging of molecular biology and computer science. 11 12 Chapter 1 1 Cells are removed from the patient. Virus containing functional gene 2 A new or corrected version of a gene is added to the cell, usually with the use of a genetically engineered virus.

Genetics also plays a critical role in medicine. Physicians recognize that many diseases and disorders have a hereditary component, including well-known genetic disorders such as sickle-cell anemia and Huntington disease as well as many common diseases such as asthma, diabetes, and hypertension. Advances in molecular genetics have allowed important insights into the nature of cancer and permitted the development of many diagnostic tests. Gene therapy—the direct alteration of genes to treat human diseases—has now been carried out on thousands of patients.

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